翻訳と辞書 Words near each other ・ Chaplygin ・ Chaplygin (crater) ・ Chaplygin (inhabited locality) ・ Chaplygin gas ・ Chaplygin problem ・ Chaplygin sleigh ・ Chaperal, Ottawa ・ Chaperina fusca ・ Chaperon (headgear) ・ Chaperone ・ Chaperone (clinical) ・ Chaperone (protein) ・ Chaperone (social) ・ Chaperone code ・ Chaperone DnaJ ・ Chaperone-assisted selective autophagy ・ Chaperone-mediated autophagy ・ Chaperone-Usher fimbriae ・ Chaperonin ・ Chaperonin ATPase ・ Chapeshlu ・ Chapeshlu District ・ Chapet ・ Chapey ・ Chapfensee ・ Chapi ・ Chapi (Peru) ・ Chapi Chapo ・ Chapi Urqu ・ Chapi-chapi Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Chaperone-assisted selective autophagy ： ウィキペディア英語版 Chaperone-assisted selective autophagy Chaperone-assisted selective autophagy (CASA) is a cellular process for the selective, ubiquitin-dependent degradation of chaperone-bound proteins in lysosomes. Autophagy (Greek: ‘self-eating’) was initially identified as a catabolic process for the unselective degradation of cellular content in lysosomes under starvation conditions. However, autophagy also comprises selective degradation pathways, which depend on ubiquitin conjugation to initiate sorting to lysosomes. In the case of CASA, dysfunctional, nonnative proteins are recognized by molecular chaperones and become ubiquitinated by chaperone-associated ubiquitin ligases. The ubiquitinated proteins are enclosed in autophagosomes, which eventually fuse with lysosomes, leading to the degradation of the dysfunctional proteins. CASA is a vital part of the cellular protein quality control system. It is essential for protein homeostais (proteostasis) in neurons and in mechanically strained cells and tissues such as skeletal muscle, heart and lung.〔 ==CASA - involved components and mechanism== The CASA complex comprises the molecular chaperones HSPA8 and HSPB8, and the cochaperones BAG3 and STUB1. BAG3 facilitates the cooperation of HSPA8 and HSPB8 during the recognition of nonnative client proteins. STUB1 mediates the ubiquitination of the chaperone-bound client, which induces the recruitment of the autophagic ubiquitin adaptor SQSTM1. The adaptor simultaneously interacts with the ubiquitinated client and autophagosome membrane precursors, thereby inducing the autophagic engulfment of the client. Autophagosome formation during CASA depends on an interaction of BAG3 with SYNPO2, which triggers the cooperation with a VPS18-containing protein complex that mediates the fusion of autophagosome membrane precursors.〔 The formed autophagosomes finally fuse with lysosomes, resulting in client degradation. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Chaperone-assisted selective autophagy」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.